Antifungal agent from the group of imidazole derivatives for topical and local application, reduces the synthesis of ergosterol, which is part of the cell membrane of the microbial cells, and causes a change in the structure and properties of the cell membrane of the microbial cell that ultimately causes the lysis of microbial cells. In tri tren side effects low concentrations fungistatic effect and in large – fungicide, not only in proliferating cells. The fungicidal concentrations interacts with mitochondrial and peroxidase enzymes, thereby increasing the concentration of hydrogen peroxide to the cell. It is active against pathogenic dermatophyte. Trichomonas vaginalis. Pharmacokinetics poorly absorbed through the skin and mucous membranes.Accumulate in the stratum corneum of the epidermis, it penetrates the nail keratin.
Dosage and administration:
Applied topically and locally. The cream is applied in a thin layer 2-3 times a day on previously cleaned and dry the affected areas of the skin and mucous membranes and rub gently. Single dose on the palm-sized surface area – cream bar 5 mm in length. The course of treatment is on average about 4 weeks, but in order to achieve full recovery should not stop treatment cream immediately after the disappearance of acute signs of inflammation or subjective complaints and continue to use the drug for a further 14 days.
The duration of therapy is individual and depends on the severity and localization of the disease. Pityriasis tri tren side effectstri tren side effects (multicolored) versicolor cured, mainly for 1-3 weeks, and erythrasma within 2-4 weeks. When fungal diseases of the feet skin before applying the cream foot wash with warm soapy water, carefully rubbing the cream, especially between the toes. When fungal skin lesions feet is recommended to continue treatment for 2-3 weeks after the relief of symptoms of the disease.
Maybe burning sensation, tingling in the field application of the cream, the appearance of erythema, blisters, swelling, irritation and flaking of the skin. Allergic reactions (pruritus, urticaria).
Interaction with other drugs:
Amphotericin B, nystatin, natamycin reduce the effectiveness of clotrimazole, while the application.
If after 4 weeks of starting treatment is not marked clinical improvement, it is necessary to conduct microbiological testing to confirm the diagnosis and rule out other causes of the disease.
If you develop an increased sensitivity or irritation when using the drug, treatment should be stopped.
We do not recommend the application of the drug to the skin in the eye area.
For successful treatment it is important to regular use of the drug.
1% cream in tubes of 20 g Tuba packed in tri tren side effects a cardboard box with instructions for use.
In a dry, dark place at a temperature no higher than 25 ° C. Keep out of the reach of children.
3 years. Do not use the drug after a certain number on the package shelf life!